4W9F

pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 5)

4W9F の概要

• エントリーDOI: 10.2210/pdb4w9f/pdb
• 分子名称: Transcription elongation factor B polypeptide 2, Transcription elongation factor B polypeptide 1, Von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
• 機能のキーワード: protein complex, ubiquitin ligase, hypoxia inducible factor, transcription, ligase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : Q15370 Q15369; Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 168611.24

構造登録者

van Molle, I.,Hewitt, S.,Galdeano, C.,Gadd, M.S.,Ciulli, A. (登録日: 2014-08-27, 公開日: 2014-09-10, 最終更新日: 2024-01-10)

• 主引用文献: Galdeano, C.,Gadd, M.S.,Soares, P.,Scaffidi, S.,Van Molle, I.,Birced, I.,Hewitt, S.,Dias, D.M.,Ciulli, A.; Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.; J.Med.Chem., 57:8657-8663, 2014; PubMed: 25166285; DOI: 10.1021/jm5011258

実験手法

X-RAY DIFFRACTION (2.1 Å)