4W97

Structure of ketosteroid transcriptional regulator KstR2 of Mycobacterium tuberculosis

4W97 の概要

• エントリーDOI: 10.2210/pdb4w97/pdb
• 分子名称: HTH-type transcriptional repressor KstR2, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-[(3aS,4S,7aS)-7a-methyl-1,5-bis(oxidanylidene)-2,3,3a,4,6,7-hexahydroinden-4-yl]propanethioate, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: cholesterol, catabolism, kstr2, transcription regulator, tetr, helix-turn-helix, structural genomics, midwest center for structural genomics, mcsg, psi-biology, transcription
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23989.37

構造登録者

Stogios, P.J.,Evdokimova, E.,Savchenko, A.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG) (登録日: 2014-08-27, 公開日: 2014-11-26, 最終更新日: 2023-09-27)

• 主引用文献: Crowe, A.M.,Stogios, P.J.,Casabon, I.,Evdokimova, E.,Savchenko, A.,Eltis, L.D.; Structural and Functional Characterization of a Ketosteroid Transcriptional Regulator of Mycobacterium tuberculosis.; J.Biol.Chem., 290:872-882, 2015; PubMed: 25406313; DOI: 10.1074/jbc.M114.607481

実験手法

X-RAY DIFFRACTION (1.6 Å)