4W4W

JNK2/3 in complex with N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide

Summary for 4W4W

• Entry DOI: 10.2210/pdb4w4w/pdb
• Related: 4W4V 4W4X 4W4Y
• Descriptor: c-Jun N-terminal kinase 3, N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide (3 entities in total)
• Functional Keywords: jnk, map kinase, isoform selective, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 42674.39

Authors

Park, H.,Iqbal, S.,Hernandez, P.,Mora, R.,Zheng, K.,Feng, Y.,LoGrasso, P. (deposition date: 2014-08-15, release date: 2015-02-11, Last modification date: 2023-12-27)

• Primary citation: Park, H.,Iqbal, S.,Hernandez, P.,Mora, R.,Zheng, K.,Feng, Y.,LoGrasso, P.; Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.; Sci Rep, 5:8047-8047, 2015; PubMed: 25623238; DOI: 10.1038/srep08047

Experimental method

X-RAY DIFFRACTION (1.9 Å)