4W2I

Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites

これはPDB形式変換不可エントリーです。

4W2I の概要

• エントリーDOI: 10.2210/pdb4w2i/pdb
• 分子名称: 16S Ribosomal RNA, 30S Ribosomal Protein S10, 30S Ribosomal Protein S11, ... (61 entities in total)
• 機能のキーワード: negamycin, antibiotic, 70s ribosome, inhibition of translation, miscoding, translocation inhibitor, 30s subunit with negamycin, mrna, deacylated a-, p-, and e-site trnas of the 1st 70s ribosome in the asu, functional complex of bacterial 70s ribosome with antibiotic negamycin, 50s subunit of the 1st 70s ribosome in the asu, ribosome-antibiotic complex, ribosome/antibiotic
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4555287.71

構造登録者

Polikanov, Y.S.,Szal, T.,Jiang, F.,Gupta, P.,Matsuda, R.,Shiozuka, M.,Steitz, T.A.,Vazquez-Laslop, N.,Mankin, A.S. (登録日: 2014-09-12, 公開日: 2014-10-15, 最終更新日: 2023-12-27)

• 主引用文献: Polikanov, Y.S.,Szal, T.,Jiang, F.,Gupta, P.,Matsuda, R.,Shiozuka, M.,Steitz, T.A.,Vazquez-Laslop, N.,Mankin, A.S.; Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA.; Mol.Cell, 56:541-550, 2014; PubMed: 25306922; DOI: 10.1016/j.molcel.2014.09.021

実験手法

X-RAY DIFFRACTION (2.7 Å)