4W2H

Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site

これはPDB形式変換不可エントリーです。

4W2H の概要

• エントリーDOI: 10.2210/pdb4w2h/pdb
• 分子名称: 16S Ribosomal RNA, 30S Ribosomal Protein S10, 30S Ribosomal Protein S11, ... (61 entities in total)
• 機能のキーワード: pactamycin, antibiotic, 70s ribosome, inhibition of translation, initiation inhibitor, 30s subunit with pactamycin (co-crystallized), mrna, deacylated p-site trna, and e-site trna acceptor stem of the 1st 70s ribosome in the asu, functional complex of bacterial 70s ribosome with antibiotic pactamycin (extended conformation), 50s subunit of the 1st 70s ribosome in the asu, ribosome-antibiotic complex, ribosome/antibiotic
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 110
• 化学式量合計: 4503125.04

構造登録者

Polikanov, Y.S.,Osterman, I.A.,Szal, T.,Tashlitsky, V.N.,Serebryakova, M.V.,Kusochek, P.,Bulkley, D.,Malanicheva, I.A.,Efimenko, T.A.,Efremenkova, O.V.,Konevega, A.L.,Shaw, K.J.,Bogdanov, A.A.,Rodnina, M.V.,Dontsova, O.A.,Mankin, A.S.,Steitz, T.A.,Sergiev, P.V. (登録日: 2014-09-12, 公開日: 2014-10-15, 最終更新日: 2023-12-27)

• 主引用文献: Polikanov, Y.S.,Osterman, I.A.,Szal, T.,Tashlitsky, V.N.,Serebryakova, M.V.,Kusochek, P.,Bulkley, D.,Malanicheva, I.A.,Efimenko, T.A.,Efremenkova, O.V.,Konevega, A.L.,Shaw, K.J.,Bogdanov, A.A.,Rodnina, M.V.,Dontsova, O.A.,Mankin, A.S.,Steitz, T.A.,Sergiev, P.V.; Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.; Mol.Cell, 56:531-540, 2014; PubMed: 25306919; DOI: 10.1016/j.molcel.2014.09.020

実験手法

X-RAY DIFFRACTION (2.7 Å)