4W1O

PDE4D complexed with inhibitor

Summary for 4W1O

Entry DOI	10.2210/pdb4w1o/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, N-(3,5-dichloropyridin-4-yl)-3-[(3-ethyl-1,2-oxazol-5-yl)methoxy]-4-methoxybenzamide, ZINC ION, ... (4 entities in total)
Functional Keywords	inhibitor, complex, pde4d, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	167338.79
Authors	Sorensen, M.D. (deposition date: 2014-08-14, release date: 2014-11-05, Last modification date: 2020-03-11)
Primary citation	Felding, J.,Sorensen, M.D.,Poulsen, T.D.,Larsen, J.,Andersson, C.,Refer, P.,Engell, K.,Ladgefoged, L.G.,Thormann, T.,Vinggaard, A.M.,Hegardt, P.,Sohoel, A.,Nielse, S.F. Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis J.Med.Chem, 57:5893-5903, 2014 Cited by PubMed: 24984230 DOI: 10.1021/jm500378a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation