4W1O

PDE4D complexed with inhibitor

4W1O の概要

• エントリーDOI: 10.2210/pdb4w1o/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, N-(3,5-dichloropyridin-4-yl)-3-[(3-ethyl-1,2-oxazol-5-yl)methoxy]-4-methoxybenzamide, ZINC ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, pde4d, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 167338.79

構造登録者

Sorensen, M.D. (登録日: 2014-08-14, 公開日: 2014-11-05, 最終更新日: 2024-05-08)

• 主引用文献: Felding, J.,Sorensen, M.D.,Poulsen, T.D.,Larsen, J.,Andersson, C.,Refer, P.,Engell, K.,Ladgefoged, L.G.,Thormann, T.,Vinggaard, A.M.,Hegardt, P.,Sohoel, A.,Nielse, S.F.; Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis; J.Med.Chem, 57:5893-5903, 2014; PubMed: 24984230; DOI: 10.1021/jm500378a

実験手法

X-RAY DIFFRACTION (2.2 Å)