4V2O

Structure of saposin B in complex with chloroquine

Summary for 4V2O

• Entry DOI: 10.2210/pdb4v2o/pdb
• Descriptor: SAPOSIN-B, N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE (3 entities in total)
• Functional Keywords: hydrolase activator, protein-ligand complex
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Lysosome . Prosaposin: Secreted: P07602
• Total number of polymer chains: 3
• Total formula weight: 27932.10

Authors

Zubieta, C.,Lai, X.,Doyle, R.P. (deposition date: 2014-10-13, release date: 2015-12-09, Last modification date: 2024-01-10)

• Primary citation: Huta, B.P.,Mehlenbacher, M.R.,Nie, Y.,Lai, X.,Zubieta, C.,Bou-Abdallah, F.,Doyle, R.P.; The Lysosomal Protein Saposin B Binds Chloroquine.; Chemmedchem, 11:277-, 2016; PubMed: 26616259; DOI: 10.1002/CMDC.201500494

Experimental method

X-RAY DIFFRACTION (2.13 Å)