4V1Z

The 3-D structure of the cellobiohydrolase, Cel7A, from Aspergillus fumigatus

4V1Z の概要

• エントリーDOI: 10.2210/pdb4v1z/pdb
• 関連するPDBエントリー: 4V20
• 分子名称: CELLOBIOHYDROLASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, cellulase, biofuels, carbohydrate-active enzyme, thermal 2 stability
• 由来する生物種: ASPERGILLUS FUMIGATUS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47489.59

構造登録者

Moroz, O.V.,Maranta, M.,Shaghasi, T.,Harris, P.V.,Wilson, K.S.,Davies, G.J. (登録日: 2014-10-04, 公開日: 2015-01-14, 最終更新日: 2024-10-16)

主引用文献

Moroz, O.V.,Maranta, M.,Shaghasi, T.,Harris, P.V.,Wilson, K.S.,Davies, G.J.
The Three-Dimensional Structure of the Cellobiohydrolase Cel7A from Aspergillus Fumigatus at 1.5 A Resolution
Acta Crystallogr.,Sect.F, 71:114-, 2015

PubMed Abstract: The enzymatic degradation of plant cell-wall cellulose is central to many industrial processes, including second-generation biofuel production. Key players in this deconstruction are the fungal cellobiohydrolases (CBHs), notably those from family GH7 of the carbohydrate-active enzymes (CAZY) database, which are generally known as CBHI enzymes. Here, three-dimensional structures are reported of the Aspergillus fumigatus CBHI Cel7A solved in uncomplexed and disaccharide-bound forms at resolutions of 1.8 and 1.5 Å, respectively. The product complex with a disaccharide in the +1 and +2 subsites adds to the growing three-dimensional insight into this family of industrially relevant biocatalysts.

PubMed: 25615982
DOI: 10.1107/S2053230X14027307

実験手法

X-RAY DIFFRACTION (1.78 Å)