4V0S

Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by a 3-dehydroquinic acid derivative

4V0S の概要

• エントリーDOI: 10.2210/pdb4v0s/pdb
• 分子名称: 3-DEHYDROQUINATE DEHYDRATASE, (1R,2S,4S,5R)-2-(2,3,4,5,6-pentafluorophenyl)methyl-1,4,5-trihydroxy-3-oxocyclohexane-1-carboxylic acid, 3,4-DIHYDROXY-2-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]BENZOIC ACID, ... (6 entities in total)
• 機能のキーワード: binding sites, type 2 dehydroquinase, lyase, inhibitor, protein binding, shikimis acid pathway, substrate specificity
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32890.28

構造登録者

Otero, J.M.,Llamas-Saiz, A.L.,Santiago, C.,Lamb, H.,Hawkins, A.R.,Maneiro, M.,Peon, A.,Gonzalez-Bello, C.,van Raaij, M.J. (登録日: 2014-09-18, 公開日: 2016-01-13, 最終更新日: 2024-01-10)

• 主引用文献: Maneiro, M.,Otero, J.M.,Peon, A.,van Raaij, M.J.,Lamb, H.,Hawkings, A.R.,Gonzalez-Bello, C.; Investigation of the Dehydratation Mechanism Catalyzed by the Type II Dehydroquinase; To be Published,

実験手法

X-RAY DIFFRACTION (1.55 Å)