4UXN

LSD1(KDM1A)-CoREST in complex with Z-Pro derivative of MC2580

4UXN の概要

• エントリーDOI: 10.2210/pdb4uxn/pdb
• 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, covalent inhibitor, tranylcypromine
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 147279.40

構造登録者

Rodriguez, V.,Valente, S.,Stazi, G.,Lucidi, A.,Mercurio, C.,Vianello, P.,Ciossani, G.,Mattevi, A.,Botrugno, O.A.,Dessanti, P.,Minucci, S.,Varasi, M.,Mai, A. (登録日: 2014-08-27, 公開日: 2015-02-25, 最終更新日: 2024-01-10)

• 主引用文献: Rodriguez, V.,Valente, S.,Rovida, S.,Rotili, D.,Stazi, G.,Lucidi, A.,Ciossani, G.,Mattevi, A.,Botrugno, O.A.,Dessanti, P.,Mercurio, C.,Vianello, P.,Minucci, S.,Varasi, M.,Mai, A.; Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells; Chemmedchem, 6:665-670, 2015; DOI: 10.1039/C4MD00507D

実験手法

X-RAY DIFFRACTION (2.85 Å)