4UUH

X-ray crystal structure of human TNKS in complex with a small molecule inhibitor

4UUH の概要

• エントリーDOI: 10.2210/pdb4uuh/pdb
• 分子名称: TANKYRASE-1, ZINC ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: transferase, tnks, inhibitor, wnt signalling
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: O95271
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30432.57

構造登録者

Oliver, A.W.,Rajasekaran, M.B.,Pearl, L.H. (登録日: 2014-07-28, 公開日: 2015-07-08, 最終更新日: 2024-01-10)

• 主引用文献: Elliot, R.J.,Jarvis, A.,Rajasekaran, M.B.,Menon, M.,Bowers, L.,Boffey, R.,Bayford, M.,Firth-Clark, S.,Beevers, R.,Aquil, R.,Kirton, S.B.,Niculescu-Duvaz, D.,Fish, L.,Lopes, F.,Mcleary, R.,Trindade, I.,Vendrell, E.,Munkonge, F.,Porter, R.,Perrior, T.,Springer, C.,Oliver, A.W.,Pearl, L.H.,Ashworth, A.,Lord, C.J.; Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors; Medchemcommm, 6:1687-, 2015; DOI: 10.1039/C5MD00210A

実験手法

X-RAY DIFFRACTION (2.52 Å)