4UPT
structure of bovine endothelial nitric oxide synthase heme domain in complex with n'-[4-[[(2s,4r)-4-[3-[(c-thiophen-2-ylcarbonimidoyl)amino]phenoxy]pyrrolidin-2-yl]methoxy]phenyl]thiophene-2-carboximidamide
Summary for 4UPT
Entry DOI | 10.2210/pdb4upt/pdb |
Related | 4UPM 4UPN 4UPO 4UPP 4UPQ 4UPR 4UPS |
Descriptor | NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | oxidoreductase, inhibitor complex |
Biological source | BOS TAURUS (CATTLE) |
Cellular location | Cell membrane: P29473 |
Total number of polymer chains | 2 |
Total formula weight | 102690.60 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2014-06-17, release date: 2014-08-20, Last modification date: 2014-09-24) |
Primary citation | Jing, Q.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Combination of Chiral Linkers with Thiophenecarboximidamide Heads to Improve the Selectivity of Inhibitors of Neuronal Nitric Oxide Synthase. Bioorg.Med.Chem.Lett., 24:4504-, 2014 Cited by PubMed: 25149509DOI: 10.1016/J.BMCL.2014.07.079 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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