4UPR

Structure of bovine endothelial nitric oxide synthase heme domain in complex with N,N''-{[(2S)-3-aminopropane-1,2-diyl]bis(oxymethanediylbenzene-3,1-diyl)}dithiophene-2-carboximidamide

Summary for 4UPR

Entry DOI	10.2210/pdb4upr/pdb
Related	4UPM 4UPN 4UPO 4UPP 4UPQ 4UPS 4UPT
Descriptor	NITRIC OXIDE SYNTHASE, ENDOTHELIAL, 5,6,7,8-TETRAHYDROBIOPTERIN, N,N''-{[(2S)-3-aminopropane-1,2-diyl]bis(oxymethanediylbenzene-3,1-diyl)}dithiophene-2-carboximidamide, ... (8 entities in total)
Functional Keywords	oxidoreductase, inhibitor complex
Biological source	BOS TAURUS (CATTLE)
Cellular location	Cell membrane: P29473
Total number of polymer chains	2
Total formula weight	102694.63
Authors	Li, H.,Poulos, T.L. (deposition date: 2014-06-17, release date: 2014-08-20, Last modification date: 2014-09-24)
Primary citation	Jing, Q.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Combination of Chiral Linkers with Thiophenecarboximidamide Heads to Improve the Selectivity of Inhibitors of Neuronal Nitric Oxide Synthase. Bioorg.Med.Chem.Lett., 24:4504-, 2014 Cited by PubMed: 25149509 DOI: 10.1016/J.BMCL.2014.07.079 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation