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4UPO

Structure of rat neuronal nitric oxide synthase heme domain in complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-imino(thiophen-2-yl)methyl]amino}benzyl)oxy]methyl}pyrrolidin-3-yl]oxy}methyl)phenyl]thiophene-2-carboximidamide

Summary for 4UPO
Entry DOI10.2210/pdb4upo/pdb
Related4UPM 4UPN 4UPP 4UPQ 4UPR 4UPS 4UPT
DescriptorNITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsoxidoreductase, inhibitor complex
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
Cellular locationCell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains2
Total formula weight100615.46
Authors
Li, H.,Poulos, T.L. (deposition date: 2014-06-17, release date: 2014-08-20, Last modification date: 2014-09-24)
Primary citationJing, Q.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Combination of Chiral Linkers with Thiophenecarboximidamide Heads to Improve the Selectivity of Inhibitors of Neuronal Nitric Oxide Synthase.
Bioorg.Med.Chem.Lett., 24:4504-, 2014
Cited by
PubMed: 25149509
DOI: 10.1016/J.BMCL.2014.07.079
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

數據於2024-03-27公開中

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