4UPN

Structure of rat neuronal nitric oxide synthase heme domain in complex with N,N''-{[(2S)-3-aminopropane-1,2-diyl]bis(oxymethanediylbenzene-3,1-diyl)}dithiophene-2-carboximidamide

4UPN の概要

• エントリーDOI: 10.2210/pdb4upn/pdb
• 関連するPDBエントリー: 4UPM 4UPO 4UPP 4UPQ 4UPR 4UPS 4UPT
• 分子名称: NEURONAL NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, inhibitor complex
• 由来する生物種: RATTUS NORVEGICUS (NORWAY RAT)
• 細胞内の位置: Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100563.38

構造登録者

Li, H.,Poulos, T.L. (登録日: 2014-06-17, 公開日: 2014-08-20, 最終更新日: 2024-05-08)

• 主引用文献: Jing, Q.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Combination of Chiral Linkers with Thiophenecarboximidamide Heads to Improve the Selectivity of Inhibitors of Neuronal Nitric Oxide Synthase.; Bioorg.Med.Chem.Lett., 24:4504-, 2014; PubMed: 25149509; DOI: 10.1016/J.BMCL.2014.07.079

実験手法

X-RAY DIFFRACTION (2.09 Å)