4UNQ
Mtb TMK in complex with compound 36
Summary for 4UNQ
Entry DOI | 10.2210/pdb4unq/pdb |
Related | 4UNN 4UNP 4UNR 4UNS |
Descriptor | THYMIDYLATE KINASE, 4-[(R)-methylsulfinyl]-2-oxo-6-[3-(trifluoromethoxy)phenyl]-1,2-dihydropyridine-3-carbonitrile, SODIUM ION, ... (4 entities in total) |
Functional Keywords | transferase, transfer (atp tmp phosphotransferase), kinase |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Total number of polymer chains | 2 |
Total formula weight | 45235.80 |
Authors | Read, J.A.,Hussein, S.,Gingell, H.,Tucker, J. (deposition date: 2014-05-30, release date: 2015-06-24, Last modification date: 2024-01-10) |
Primary citation | Naik, M.,Raichurkar, A.,Bandodkar, B.S.,Varun, B.V.,Bhat, S.,Kalkhambkar, R.,Murugan, K.,Menon, R.,Bhat, J.,Paul, B.,Iyer, H.,Hussein, S.,Tucker, J.A.,Vogtherr, M.,Embrey, K.J.,Mcmiken, H.,Prasad, S.,Gill, A.,Ugarkar, B.G.,Venkatraman, J.,Read, J.,Panda, M. Structure Guided Lead Generation for M. Tuberculosis Thymidylate Kinase (Mtb Tmk): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-One as Potent Inhibitors. J.Med.Chem., 58:753-, 2015 Cited by PubMed: 25486447DOI: 10.1021/JM5012947 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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