4UHT

Crystal structure of the DNA binding domain of CpxR from E. coli

4UHT の概要

• エントリーDOI: 10.2210/pdb4uht/pdb
• 関連するPDBエントリー: 4UHJ 4UHK 4UHS
• 分子名称: TRANSCRIPTIONAL REGULATORY PROTEIN CPXR, CHLORIDE ION (3 entities in total)
• 機能のキーワード: transcription
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23119.21

構造登録者

Mechaly, A.E.,Alzari, P.M.A. (登録日: 2015-03-25, 公開日: 2016-04-13, 最終更新日: 2024-05-08)

主引用文献

Mechaly, A.E.,Haouz, A.,Sassoon, N.,Buschiazzo, A.,Betton, J.M.,Alzari, P.M.
Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.
J. Struct. Biol., 204:165-171, 2018

PubMed Abstract: The transcriptional regulator CpxR mediates an adaptive response to envelope stress, tightly linked to virulence and antibiotics resistance in several Gammaproteobacteria pathogens. In this work, we integrated crystallographic and small-angle X-ray scattering data to gain insights into the structure and conformational plasticity of CpxR from Escherichia coli. CpxR dimerizes through two alternative interaction surfaces. Moreover, widely different CpxR conformations coexist in solution, from compact to fully extended ones. The possible functional implications of these structural features are discussed.

PubMed: 30086390
DOI: 10.1016/j.jsb.2018.08.001

実験手法

X-RAY DIFFRACTION (1.15 Å)