4UH3

Structure of rat neuronal nitric oxide synthase heme domain in complex with N1-(3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5- fluorophenyl)-N1,N2-dimethylethane-1,2-diamine

4UH3 の概要

• エントリーDOI: 10.2210/pdb4uh3/pdb
• 関連するPDBエントリー: 4UGZ 4UH0 4UH1 4UH2 4UH4 4UH5 4UH6 4UH7 4UH8 4UH9 4UHA
• 分子名称: NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, inhibitor complex
• 由来する生物種: RATTUS NORVEGICUS (NORWAY RAT)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100156.85

構造登録者

Li, H.,Poulos, T.L. (登録日: 2015-03-23, 公開日: 2015-07-15, 最終更新日: 2024-05-08)

• 主引用文献: Kang, S.,Li, H.,Tang, W.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; 2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.; J.Med.Chem., 58:5548-, 2015; PubMed: 26120733; DOI: 10.1021/ACS.JMEDCHEM.5B00573

実験手法

X-RAY DIFFRACTION (2.03 Å)