4UDU

Crystal structure of staphylococcal enterotoxin E in complex with a T cell receptor

4UDU の概要

• エントリーDOI: 10.2210/pdb4udu/pdb
• 関連するPDBエントリー: 4UDT
• 分子名称: T CELL RECEPTOR ALPHA CHAIN, T-CELL RECEPTOR ALPHA CHAIN C REGION, PROTEIN TRBV7-9, T-CELL RECEPTOR BETA-2 CHAIN C REGION, ENTEROTOXIN TYPE E, ... (6 entities in total)
• 機能のキーワード: immune system, superantigen, t cell receptor, major histocompatibility complex
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Membrane ; Single-pass membrane protein : P01848 A0A5B9; Secreted: P12993
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 77496.29

構造登録者

Rodstrom, K.E.J.,Regenthal, P.,Lindkvist-Petersson, K. (登録日: 2014-12-11, 公開日: 2015-06-24, 最終更新日: 2024-10-16)

主引用文献

Rodstrom, K.E.J.,Regenthal, P.,Lindkvist-Petersson, K.
Structure of Staphylococcal Enterotoxin E in Complex with Tcr Defines the Role of Tcr Loop Positioning in Superantigen Recognition.
Plos One, 10:01319-, 2015

PubMed Abstract: T cells are crucial players in cell-mediated immunity. The specificity of their receptor, the T cell receptor (TCR), is central for the immune system to distinguish foreign from host antigens. Superantigens are bacterial toxins capable of inducing a toxic immune response by cross-linking the TCR and the major histocompatibility complex (MHC) class II and circumventing the antigen specificity. Here, we present the structure of staphylococcal enterotoxin E (SEE) in complex with a human T cell receptor, as well as the unligated T cell receptor structure. There are clear structural changes in the TCR loops upon superantigen binding. In particular, the HV4 loop moves to circumvent steric clashes upon complex formation. In addition, a predicted ternary model of SEE in complex with both TCR and MHC class II displays intermolecular contacts between the TCR α-chain and the MHC, suggesting that the TCR α-chain is of importance for complex formation.

PubMed: 26147596
DOI: 10.1371/JOURNAL.PONE.0131988

実験手法

X-RAY DIFFRACTION (2.5 Å)