4UBT
Structure of the C93S variant of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis in complex with a steroid and CoA.
Summary for 4UBT
Entry DOI | 10.2210/pdb4ubt/pdb |
Descriptor | Acetyl-CoA acetyltransferase FadA5, COENZYME A, (2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoic acid (non-preferred name), ... (8 entities in total) |
Functional Keywords | degradative thiolase, steroid-complex, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 174370.33 |
Authors | Schaefer, C.M.,Kisker, C. (deposition date: 2014-08-13, release date: 2014-12-17, Last modification date: 2023-12-20) |
Primary citation | Schaefer, C.M.,Lu, R.,Nesbitt, N.M.,Schiebel, J.,Sampson, N.S.,Kisker, C. FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis. Structure, 23:21-33, 2015 Cited by PubMed: 25482540DOI: 10.1016/j.str.2014.10.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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