4UB7

High-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26) showing an extreme distortion of the ATP-binding loop combined with a pi-halogen bond

4UB7 の概要

• エントリーDOI: 10.2210/pdb4ub7/pdb
• 関連するPDBエントリー: 1JWH
• 分子名称: Casein kinase II subunit alpha, 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein kinase ck2, atp-competitive inhibitors, halogen bond, 4'-carboxy-6, 8-bromo-flavonol, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40613.14

構造登録者

Niefind, K.,Bischoff, N.,Guerra, B.,Golub, A.,Issinger, O.-G. (登録日: 2014-08-12, 公開日: 2015-07-01, 最終更新日: 2024-05-08)

• 主引用文献: Guerra, B.,Bischoff, N.,Bdzhola, V.G.,Yarmoluk, S.M.,Issinger, O.G.,Golub, A.G.,Niefind, K.; A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.; Acs Chem.Biol., 10:1654-1660, 2015; PubMed: 25961323; DOI: 10.1021/acschembio.5b00235

実験手法

X-RAY DIFFRACTION (2.1 Å)