4UAL

MRCK beta in complex with BDP00005290

Summary for 4UAL

Entry DOI	10.2210/pdb4ual/pdb
Descriptor	Serine/threonine-protein kinase MRCK beta, 4-chloro-1-(piperidin-4-yl)-N-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-1H-pyrazole-3-carboxamide, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	myotonic dystrophy kinase-related cdc42-binding kinase, metastasis, cell invasion, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9Y5S2
Total number of polymer chains	1
Total formula weight	48528.17
Authors	Schuettelkopf, A.W. (deposition date: 2014-08-10, release date: 2014-10-22, Last modification date: 2023-12-20)
Primary citation	Unbekandt, M.,Croft, D.R.,Crighton, D.,Mezna, M.,McArthur, D.,McConnell, P.,Schuttelkopf, A.W.,Belshaw, S.,Pannifer, A.,Sime, M.,Bower, J.,Drysdale, M.,Olson, M.F. A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Commun. Signal, 12:54-54, 2014 Cited by PubMed: 25288205 DOI: 10.1186/PREACCEPT-1467335606136283 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation