4U9M

Structure of the DNA duplex d(ATTAAT)2 with Hoogsteen hydrogen bonds

Summary for 4U9M

• Entry DOI: 10.2210/pdb4u9m/pdb
• Descriptor: DNA (5'-D(*AP*TP*TP*AP*AP*T)-3') (1 entity in total)
• Functional Keywords: dna
• Biological source: synthetic construct
• Total number of polymer chains: 5
• Total formula weight: 9036.20

Authors

Acosta-Reyes, F.J.,Alechaga, E.,Subirana, J.A.,Campos, J.L. (deposition date: 2014-08-06, release date: 2015-04-01, Last modification date: 2023-12-20)

Primary citation

Acosta-Reyes, F.J.,Alechaga, E.,Subirana, J.A.,Campos, J.L.
Structure of the DNA Duplex d(ATTAAT)2 with Hoogsteen Hydrogen Bonds.
Plos One, 10:e0120241-e0120241, 2015

PubMed Abstract: The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)2, which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations.

PubMed: 25781995
DOI: 10.1371/journal.pone.0120241

Experimental method

X-RAY DIFFRACTION (3.13 Å)