4U90

GephE in complex with PEG crosslinked GABA receptor alpha3 subunit derived dimeric peptide

4U90 の概要

• エントリーDOI: 10.2210/pdb4u90/pdb
• 関連するPDBエントリー: 4PD0 4PD1 4TK1 4TK2 4TK3 4TK4 4U91
• 分子名称: Gephyrin, Gamma-aminobutyric acid receptor subunit alpha-3, 1,4-BUTANEDIOL, ... (5 entities in total)
• 機能のキーワード: inhibitory synapse, scaffolding protein, gaba type a receptor, transferase, transfer protein - structural protein complex, transfer protein / structural protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cell junction, synapse : Q03555; Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein: P20236
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48279.34

構造登録者

Kasaragod, V.B.,Maric, H.M.,Schindelin, H. (登録日: 2014-08-05, 公開日: 2014-12-10, 最終更新日: 2023-12-20)

• 主引用文献: Maric, H.M.,Kasaragod, V.B.,Haugaard-Kedstrom, L.,Hausrat, T.J.,Kneussel, M.,Schindelin, H.,Strmgaard, K.; Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors.; Angew.Chem.Int.Ed.Engl., 54:490-494, 2015; PubMed: 25413248; DOI: 10.1002/anie.201409043

実験手法

X-RAY DIFFRACTION (2 Å)