4U8Z
Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06447475)
Summary for 4U8Z
Entry DOI | 10.2210/pdb4u8z/pdb |
Descriptor | Serine/threonine-protein kinase 24, MANGANESE (II) ION, 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile, ... (4 entities in total) |
Functional Keywords | mst3, pyrrolopyrimidine, inhibitor, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y6E0 |
Total number of polymer chains | 1 |
Total formula weight | 33315.04 |
Authors | Jasti, J.,Song, X.,Griffor, M.,Kurumbail, R.G. (deposition date: 2014-08-05, release date: 2015-03-18, Last modification date: 2023-09-27) |
Primary citation | Henderson, J.L.,Kormos, B.L.,Hayward, M.M.,Coffman, K.J.,Jasti, J.,Kurumbail, R.G.,Wager, T.T.,Verhoest, P.R.,Noell, G.S.,Chen, Y.,Needle, E.,Berger, Z.,Steyn, S.J.,Houle, C.,Hirst, W.D.,Galatsis, P. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J.Med.Chem., 58:419-432, 2015 Cited by PubMed: 25353650DOI: 10.1021/jm5014055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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