4U8A

Crystal structure of D(CGCGAATTCGCG)2 complexed with BPH-1503

Summary for 4U8A

• Entry DOI: 10.2210/pdb4u8a/pdb
• Related: 4U8B 4U8C
• Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, N,N'-bis[3-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]biphenyl-4,4'-dicarboxamide, ... (4 entities in total)
• Functional Keywords: antibacterial agents, bisamidines, minor groove binders, models, molecular, nucleic acid conformation, oligodeoxyribonucleotides, dna-antibiotic complex, dna/antibiotic
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 7907.75

Authors

Zhu, W.,Oldfield, E. (deposition date: 2014-08-01, release date: 2015-02-04, Last modification date: 2023-09-27)

• Primary citation: Zhu, W.,Wang, Y.,Li, K.,Gao, J.,Huang, C.H.,Chen, C.C.,Ko, T.P.,Zhang, Y.,Guo, R.T.,Oldfield, E.; Antibacterial drug leads: DNA and enzyme multitargeting.; J.Med.Chem., 58:1215-1227, 2015; PubMed: 25574764; DOI: 10.1021/jm501449u

Experimental method

X-RAY DIFFRACTION (1.48 Å)