4U80

MEK 1 kinase bound to G799

4U80 の概要

• エントリーDOI: 10.2210/pdb4u80/pdb
• 関連するPDBエントリー: 1S9J 4U7Z 4U81
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 3-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)furo[3,2-c]pyridine-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: kinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38831.49

構造登録者

Ultsch, M.H.,Robarge, K.D.,Weismann, C. (登録日: 2014-07-31, 公開日: 2014-09-24, 最終更新日: 2023-09-27)

• 主引用文献: Robarge, K.D.,Lee, W.,Eigenbrot, C.,Ultsch, M.,Wiesmann, C.,Heald, R.,Price, S.,Hewitt, J.,Jackson, P.,Savy, P.,Burton, B.,Choo, E.F.,Pang, J.,Boggs, J.,Yang, A.,Yang, X.,Baumgardner, M.; Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.; Bioorg.Med.Chem.Lett., 24:4714-4723, 2014; PubMed: 25193232; DOI: 10.1016/j.bmcl.2014.08.008

実験手法

X-RAY DIFFRACTION (2.8 Å)