4U5M

Structure of a left-handed DNA G-quadruplex

Summary for 4U5M

• Entry DOI: 10.2210/pdb4u5m/pdb
• Descriptor: DNA (28-MER), POTASSIUM ION, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: dna, quadruplex
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 9053.35

Authors

Schmitt, E.,Mechulam, Y.,Phan, A.T.,Brahim, H.,Chung, W.J.,Lim, K.W. (deposition date: 2014-07-25, release date: 2015-02-25, Last modification date: 2024-05-08)

Primary citation

Chung, W.J.,Heddi, B.,Schmitt, E.,Lim, K.W.,Mechulam, Y.,Phan, A.T.
Structure of a left-handed DNA G-quadruplex.
Proc.Natl.Acad.Sci.USA, 112:2729-2733, 2015

PubMed Abstract: Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.

PubMed: 25695967
DOI: 10.1073/pnas.1418718112

Experimental method

X-RAY DIFFRACTION (1.5 Å)