4U5M

Structure of a left-handed DNA G-quadruplex

4U5M の概要

• エントリーDOI: 10.2210/pdb4u5m/pdb
• 分子名称: DNA (28-MER), POTASSIUM ION, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: dna, quadruplex
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9053.35

構造登録者

Schmitt, E.,Mechulam, Y.,Phan, A.T.,Brahim, H.,Chung, W.J.,Lim, K.W. (登録日: 2014-07-25, 公開日: 2015-02-25, 最終更新日: 2024-05-08)

主引用文献

Chung, W.J.,Heddi, B.,Schmitt, E.,Lim, K.W.,Mechulam, Y.,Phan, A.T.
Structure of a left-handed DNA G-quadruplex.
Proc.Natl.Acad.Sci.USA, 112:2729-2733, 2015

PubMed Abstract: Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.

PubMed: 25695967
DOI: 10.1073/pnas.1418718112

実験手法

X-RAY DIFFRACTION (1.5 Å)