4TW8

The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL

4TW8 の概要

• エントリーDOI: 10.2210/pdb4tw8/pdb
• 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP4, 2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetyl)amino]methyl}-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid (3 entities in total)
• 機能のキーワード: fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, ligand selectivity, isomerase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytosol : Q02790
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55118.41

構造登録者

Gaali, S.,Kirschner, A.,Cuboni, S.,Hartmann, J.,Kozany, C.,Balsevich, G.,Namendorf, C.,Fernandez-Vizarra, P.,Almeida, O.F.X.,Ruehter, G.,Uhr, M.,Schmidt, M.V.,Touma, C.,Bracher, A.,Hausch, F. (登録日: 2014-06-30, 公開日: 2014-11-26, 最終更新日: 2023-12-20)

• 主引用文献: Gaali, S.,Kirschner, A.,Cuboni, S.,Hartmann, J.,Kozany, C.,Balsevich, G.,Namendorf, C.,Fernandez-Vizarra, P.,Sippel, C.,Zannas, A.S.,Draenert, R.,Binder, E.B.,Almeida, O.F.,Ruhter, G.,Uhr, M.,Schmidt, M.V.,Touma, C.,Bracher, A.,Hausch, F.; Selective inhibitors of the FK506-binding protein 51 by induced fit.; Nat.Chem.Biol., 11:33-37, 2015; PubMed: 25436518; DOI: 10.1038/nchembio.1699

実験手法

X-RAY DIFFRACTION (3.003 Å)