4TVM

Structure of Citrate Synthase from Mycobacterium tuberculosis

4TVM の概要

• エントリーDOI: 10.2210/pdb4tvm/pdb
• 分子名称: Citrate synthase, OXALOACETATE ION (3 entities in total)
• 機能のキーワード: krebs cycle, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48132.28

構造登録者

Ferraris, D.M.,Rizzi, M. (登録日: 2014-06-27, 公開日: 2015-01-14, 最終更新日: 2023-12-20)

主引用文献

Ferraris, D.M.,Spallek, R.,Oehlmann, W.,Singh, M.,Rizzi, M.
Structures of citrate synthase and malate dehydrogenase of Mycobacterium tuberculosis.
Proteins, 83:389-394, 2015

PubMed Abstract: The tricarboxylic acid (TCA) cycle is a central metabolic pathway of all aerobic organisms and is responsible for the synthesis of many important precursors and molecules. TCA cycle plays a key role in the metabolism of Mycobacterium tuberculosis and is involved in the adaptation process of the bacteria to the host immune response. We present here the first crystal structures of M. tuberculosis malate dehydrogenase and citrate synthase, two consecutive enzymes of the TCA, at 2.6 Å and 1.5 Å resolution, respectively. General analogies and local differences with the previously reported homologous protein structures are described.

PubMed: 25524525
DOI: 10.1002/prot.24743

実験手法

X-RAY DIFFRACTION (2.6 Å)