4TVK

TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR

4TVK の概要

• エントリーDOI: 10.2210/pdb4tvk/pdb
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: multitarget drug, enzyme-inhibitor complex, tacrine, quinone, hydrolase
• 由来する生物種: Torpedo californica (Pacific electric ray)
• 細胞内の位置: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61761.94

構造登録者

Pesaresi, A.,Samez, S.,Lamba, D. (登録日: 2014-06-27, 公開日: 2014-10-08, 最終更新日: 2023-12-20)

• 主引用文献: Nepovimova, E.,Uliassi, E.,Korabecny, J.,Pena-Altamira, L.E.,Samez, S.,Pesaresi, A.,Garcia, G.E.,Bartolini, M.,Andrisano, V.,Bergamini, C.,Fato, R.,Lamba, D.,Roberti, M.,Kuca, K.,Monti, B.,Bolognesi, M.L.; Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects.; J.Med.Chem., 57:8576-8589, 2014; PubMed: 25259726; DOI: 10.1021/jm5010804

実験手法

X-RAY DIFFRACTION (2.3 Å)