4TRJ

Crystal structure of Mycobacterium tuberculosis enoyl reductase (INHA) complexed with N-(3-bromophenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide, refined with new ligand restraints

「2H7L」から置き換えられました

4TRJ の概要

• エントリーDOI: 10.2210/pdb4trj/pdb
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, pyrrolidine carboxamide
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29583.47

構造登録者

He, X.,Alian, A.,Stroud, R.M.,Ortiz de Montellano, P.R. (登録日: 2014-06-17, 公開日: 2014-08-13, 最終更新日: 2023-12-27)

• 主引用文献: He, X.,Alian, A.,Stroud, R.M.,Ortiz de Montellano, P.R.; Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis; J. Med. Chem., :6308-6323, 2006; PubMed: 17034137; DOI: 10.1021/JM060715Y

実験手法

X-RAY DIFFRACTION (1.73 Å)