4TMF

Crystal structure of human CD38 in complex with hydrolysed compound JMS713

4TMF の概要

• エントリーDOI: 10.2210/pdb4tmf/pdb
• 分子名称: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 5-O-[(R)-{[(S)-[4-(8-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)butoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D- ribofuranose (3 entities in total)
• 機能のキーワード: cd38, adp-ribosyl cyclase, cyclic adp-ribose, x-crystallography, calcium signaling, inhibitory compound, jms713, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60656.09

構造登録者

Zhang, H.,Swarbrick, J.,Potter, B.,Hao, Q. (登録日: 2014-06-01, 公開日: 2015-05-13, 最終更新日: 2023-09-27)

• 主引用文献: Swarbrick, J.M.,Graeff, R.,Zhang, H.,Thomas, M.P.,Hao, Q.,Potter, B.V.; Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.; J.Med.Chem., 57:8517-8529, 2014; PubMed: 25226087; DOI: 10.1021/jm501037u

実験手法

X-RAY DIFFRACTION (2.05 Å)