4TL5

Crystal Structure of Human Transthyretin Ser85Pro Mutant

Summary for 4TL5

• Entry DOI: 10.2210/pdb4tl5/pdb
• Related: 4TKW 4TL4 4TLK 4TLS
• Descriptor: Transthyretin, SODIUM ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: human transthyretin, amyloid, transthyretin, mutant, transport protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 27917.66

Authors

Saelices, L.,Cascio, D.,Sawaya, M.,Eisenberg, D.S. (deposition date: 2014-05-28, release date: 2015-10-21, Last modification date: 2023-12-27)

• Primary citation: Saelices, L.,Johnson, L.M.,Liang, W.Y.,Sawaya, M.R.,Cascio, D.,Ruchala, P.,Whitelegge, J.,Jiang, L.,Riek, R.,Eisenberg, D.S.; Uncovering the Mechanism of Aggregation of Human Transthyretin.; J.Biol.Chem., 290:28932-28943, 2015; PubMed: 26459562; DOI: 10.1074/jbc.M115.659912

Experimental method

X-RAY DIFFRACTION (1.44 Å)