4S0S

STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN with ADNECTIN-1

4S0S の概要

• エントリーDOI: 10.2210/pdb4s0s/pdb
• 関連するPDBエントリー: 1XHD 4S0T
• 分子名称: Nuclear receptor subfamily 1 group I member 2, Adnectin-1 (2 entities in total)
• 機能のキーワード: pregnane x receptor, pxr, ligand binding domain, steroid receptor coactivator-1; ccr1, chemokine receptor-1; nr, nuclear receptor; af, activation function; cyp, cytochrome p450; mdr1, multi-drug resistance gene-1, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus : O75469
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 98912.82

構造登録者

Khan, J.A. (登録日: 2015-01-05, 公開日: 2015-02-11, 最終更新日: 2024-02-28)

• 主引用文献: Khan, J.A.,Camac, D.M.,Low, S.,Tebben, A.J.,Wensel, D.L.,Wright, M.C.,Su, J.,Jenny, V.,Gupta, R.D.,Ruzanov, M.,Russo, K.A.,Bell, A.,An, Y.,Bryson, J.W.,Gao, M.,Gambhire, P.,Baldwin, E.T.,Gardner, D.,Cavallaro, C.L.,Duncia, J.V.,Hynes, J.; Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR.; J.Mol.Biol., 427:924-942, 2015; PubMed: 25579995; DOI: 10.1016/j.jmb.2014.12.022

実験手法

X-RAY DIFFRACTION (2.8 Å)