4RYL

Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea

Summary for 4RYL

Entry DOI	10.2210/pdb4ryl/pdb
Descriptor	PRMT3 protein, 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, UNKNOWN ATOM OR ION, ... (4 entities in total)
Functional Keywords	prmt3, sgc707, structural genomics, structural genomics consortium, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38580.25
Authors	Dong, A.,Dobrovetsky, E.,Kaniskan, H.U.,Szewczyk, M.,Yu, Z.,Eram, M.S.,Yang, X.,Schmidt, K.,Luo, X.,Dai, M.,He, F.,Zang, I.,Lin, Y.,Kennedy, S.,Li, F.,Tempel, W.,Smil, D.,Min, S.J.,Landon, M.,Lin-Jones, J.,Huang, X.P.,Roth, B.L.,Schapira, M.,Atadja, P.,Barsyte-Lovejoy, D.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Zhao, K.,Jin, J.,Vedadi, M.,Structural Genomics Consortium (SGC) (deposition date: 2014-12-15, release date: 2015-02-25, Last modification date: 2023-09-20)
Primary citation	Kaniskan, H.U.,Szewczyk, M.M.,Yu, Z.,Eram, M.S.,Yang, X.,Schmidt, K.,Luo, X.,Dai, M.,He, F.,Zang, I.,Lin, Y.,Kennedy, S.,Li, F.,Dobrovetsky, E.,Dong, A.,Smil, D.,Min, S.J.,Landon, M.,Lin-Jones, J.,Huang, X.P.,Roth, B.L.,Schapira, M.,Atadja, P.,Barsyte-Lovejoy, D.,Arrowsmith, C.H.,Brown, P.J.,Zhao, K.,Jin, J.,Vedadi, M. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl., 54:5166-5170, 2015 Cited by PubMed: 25728001 DOI: 10.1002/anie.201412154 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation