4RYL

Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea

4RYL の概要

• エントリーDOI: 10.2210/pdb4ryl/pdb
• 分子名称: PRMT3 protein, 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, UNKNOWN ATOM OR ION, ... (4 entities in total)
• 機能のキーワード: prmt3, sgc707, structural genomics, structural genomics consortium, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38580.25

構造登録者

Dong, A.,Dobrovetsky, E.,Kaniskan, H.U.,Szewczyk, M.,Yu, Z.,Eram, M.S.,Yang, X.,Schmidt, K.,Luo, X.,Dai, M.,He, F.,Zang, I.,Lin, Y.,Kennedy, S.,Li, F.,Tempel, W.,Smil, D.,Min, S.J.,Landon, M.,Lin-Jones, J.,Huang, X.P.,Roth, B.L.,Schapira, M.,Atadja, P.,Barsyte-Lovejoy, D.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Zhao, K.,Jin, J.,Vedadi, M.,Structural Genomics Consortium (SGC) (登録日: 2014-12-15, 公開日: 2015-02-25, 最終更新日: 2023-09-20)

• 主引用文献: Kaniskan, H.U.,Szewczyk, M.M.,Yu, Z.,Eram, M.S.,Yang, X.,Schmidt, K.,Luo, X.,Dai, M.,He, F.,Zang, I.,Lin, Y.,Kennedy, S.,Li, F.,Dobrovetsky, E.,Dong, A.,Smil, D.,Min, S.J.,Landon, M.,Lin-Jones, J.,Huang, X.P.,Roth, B.L.,Schapira, M.,Atadja, P.,Barsyte-Lovejoy, D.,Arrowsmith, C.H.,Brown, P.J.,Zhao, K.,Jin, J.,Vedadi, M.; A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).; Angew.Chem.Int.Ed.Engl., 54:5166-5170, 2015; PubMed: 25728001; DOI: 10.1002/anie.201412154

実験手法

X-RAY DIFFRACTION (2.1 Å)