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4RYG

RENIN IN COMPLEXED WITH N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide INHIBITOR

Summary for 4RYG
Entry DOI10.2210/pdb4ryg/pdb
Related4RYC
DescriptorRenin, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide, ... (6 entities in total)
Functional Keywordshydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens
Cellular locationSecreted: P00797
Total number of polymer chains2
Total formula weight76296.12
Authors
Ostermann, N. (deposition date: 2014-12-15, release date: 2015-03-25, Last modification date: 2021-06-30)
Primary citationLorthiois, E.,Cumin, F.,Ehrhardt, C.,Kosaka, T.,Sellner, H.,Ostermann, N.,Francotte, E.,Wagner, T.,Maibaum, J.
trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: Prime site exploration using an amino linker.
Bioorg.Med.Chem.Lett., 25:1782-1786, 2015
Cited by
PubMed: 25782742
DOI: 10.1016/j.bmcl.2015.02.039
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

건을2024-03-27부터공개중

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