4RYG
RENIN IN COMPLEXED WITH N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide INHIBITOR
Summary for 4RYG
Entry DOI | 10.2210/pdb4ryg/pdb |
Related | 4RYC |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide, ... (6 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76296.12 |
Authors | Ostermann, N. (deposition date: 2014-12-15, release date: 2015-03-25, Last modification date: 2021-06-30) |
Primary citation | Lorthiois, E.,Cumin, F.,Ehrhardt, C.,Kosaka, T.,Sellner, H.,Ostermann, N.,Francotte, E.,Wagner, T.,Maibaum, J. trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: Prime site exploration using an amino linker. Bioorg.Med.Chem.Lett., 25:1782-1786, 2015 Cited by PubMed: 25782742DOI: 10.1016/j.bmcl.2015.02.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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