4RW6
Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor
4RW6 の概要
エントリーDOI | 10.2210/pdb4rw6/pdb |
関連するPDBエントリー | 1JKH 1JLA 1JLC 3BGR 4H4M 4I2Q 4LSL 4MFB 4RW4 4RW7 4RW8 4RW9 |
分子名称 | Reverse transcriptase/ribonuclease H, p66 subunit, Reverse transcriptase/ribonuclease H, p51 subunit, (2E)-3-(3-chloro-5-{4-chloro-2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, ... (4 entities in total) |
機能のキーワード | polymerase, transferase, hydrolase, rnaseh, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Human immunodeficiency virus type 1 BH10 (HIV-1) 詳細 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 114412.96 |
構造登録者 | |
主引用文献 | Frey, K.M.,Puleo, D.E.,Spasov, K.A.,Bollini, M.,Jorgensen, W.L.,Anderson, K.S. Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants. J.Med.Chem., 58:2737-2745, 2015 Cited by PubMed: 25700160DOI: 10.1021/jm501908a 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.631 Å) |
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