4RVK

CHK1 kinase domain with diazacarbazole compound 8: N-[3-(6-cyano-9H-pyrrolo[2,3-b:5,4-c']dipyridin-3-yl)phenyl]acetamide

4RVK の概要

• エントリーDOI: 10.2210/pdb4rvk/pdb
• 関連するPDBエントリー: 4RVL
• 分子名称: Serine/threonine-protein kinase Chk1, N-[3-(6-cyano-9H-pyrrolo[2,3-b:5,4-c']dipyridin-3-yl)phenyl]acetamide (3 entities in total)
• 機能のキーワード: protein kinase, phosphotransfer catalyst, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O14757
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34532.54

構造登録者

Wiesmann, C.,Wu, P. (登録日: 2014-11-26, 公開日: 2015-06-03, 最終更新日: 2023-09-20)

• 主引用文献: Gazzard, L.,Williams, K.,Chen, H.,Axford, L.,Blackwood, E.,Burton, B.,Chapman, K.,Crackett, P.,Drobnick, J.,Ellwood, C.,Epler, J.,Flagella, M.,Gancia, E.,Gill, M.,Goodacre, S.,Halladay, J.,Hewitt, J.,Hunt, H.,Kintz, S.,Lyssikatos, J.,Macleod, C.,Major, S.,Medard, G.,Narukulla, R.,Ramiscal, J.,Schmidt, S.,Seward, E.,Wiesmann, C.,Wu, P.,Yee, S.,Yen, I.,Malek, S.; Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.; J.Med.Chem., 58:5053-5074, 2015; PubMed: 25988399; DOI: 10.1021/acs.jmedchem.5b00464

実験手法

X-RAY DIFFRACTION (1.85 Å)