4RVI

Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL0519

4RVI の概要

• エントリーDOI: 10.2210/pdb4rvi/pdb
• 関連するPDBエントリー: 4HLA 4NJS 4NJT 4NJU 4NJV 4RVJ 4RVV 4RVX
• 分子名称: HIV-1 protease, (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate (3 entities in total)
• 機能のキーワード: hiv-1 protease-inhibitor complex, grl0519, g52, protease inhibitor, non-peptidic protease inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 44572.27

構造登録者

Yedidi, R.S.,Garimella, H.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Ghosh, A.K.,Mitsuya, H. (登録日: 2014-11-26, 公開日: 2016-05-04, 最終更新日: 2024-02-28)

• 主引用文献: Yedidi, R.S.,Maeda, K.,Aoki, M.,Garimella, H.,Rao, K.V.,Akasapu, S.,Davis, D.A.,Kaufman, J.D.,Das, D.,Wingfield, P.T.,Amano, M.,Ghosh, A.K.,Mitsuya, H.; Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1; To be Published,

実験手法

X-RAY DIFFRACTION (1.99 Å)