4RVA
A triple mutant in the omega-loop of TEM-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for deacylation
Summary for 4RVA
| Entry DOI | 10.2210/pdb4rva/pdb |
| Related | 1BTL |
| Descriptor | Beta-lactamase TEM, BICARBONATE ION (3 entities in total) |
| Functional Keywords | globular, beta-lactamase, hydrolase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 28957.93 |
| Authors | Stojanoski, V.,Chow, D.-C.,Hu, L.,Sankaran, B.,Gilbert, H.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2014-11-25, release date: 2015-03-04, Last modification date: 2023-09-20) |
| Primary citation | Stojanoski, V.,Chow, D.C.,Hu, L.,Sankaran, B.,Gilbert, H.F.,Prasad, B.V.,Palzkill, T. A Triple Mutant in the Omega-loop of TEM-1 beta-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis. J.Biol.Chem., 290:10382-10394, 2015 Cited by PubMed: 25713062DOI: 10.1074/jbc.M114.633438 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.4397 Å) |
Structure validation
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