4RUN

Crystal structure of human odorant binding protein OBPIIa

4RUN の概要

• エントリーDOI: 10.2210/pdb4run/pdb
• 分子名称: Odorant-binding protein 2a, CITRATE ANION (3 entities in total)
• 機能のキーワード: human lipocalin, lipid binding protein, odorant binding protein, vanillin, lilial, fatty acids, aliphatic aldehydes, nasal mucus, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted : Q9NY56
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37499.66

構造登録者

Schiefner, A.,Skerra, A. (登録日: 2014-11-21, 公開日: 2015-04-08, 最終更新日: 2024-11-27)

主引用文献

Schiefner, A.,Freier, R.,Eichinger, A.,Skerra, A.
Crystal structure of the human odorant binding protein, OBPIIa.
Proteins, 83:1180-1184, 2015

PubMed Abstract: Human odorant-binding protein, OBPIIa , is expressed by nasal epithelia to facilitate transport of hydrophobic odorant molecules across the aqueous mucus. Here, we report its crystallographic analysis at 2.6 Å resolution. OBPIIa is a monomeric protein that exhibits the classical lipocalin fold with a conserved eight-stranded β-barrel harboring a remarkably large hydrophobic pocket. Basic residues within the four loops that shape the entrance to this ligand-binding site evoke a positive electrostatic potential. Human OBPIIa shows distinct features compared with other mammalian OBPs, including a potentially reactive Cys side chain within its pocket similar to human tear lipocalin.

PubMed: 25810031
DOI: 10.1002/prot.24797

実験手法

X-RAY DIFFRACTION (2.6 Å)