4RJ7
EGFR kinase (T790M/L858R) with inhibitor compound 1
4RJ7 の概要
エントリーDOI | 10.2210/pdb4rj7/pdb |
関連するPDBエントリー | 4RJ3 4RJ4 4RJ5 4RJ6 4RJ8 |
分子名称 | Epidermal growth factor receptor, SULFATE ION, 2,6-dichloro-N-{2-[(2-{[(2S)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide, ... (4 entities in total) |
機能のキーワード | protein kinase, phosphotransfer catalyst, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 38092.78 |
構造登録者 | |
主引用文献 | Hanan, E.J.,Eigenbrot, C.,Bryan, M.C.,Burdick, D.J.,Chan, B.K.,Chen, Y.,Dotson, J.,Heald, R.A.,Jackson, P.S.,La, H.,Lainchbury, M.D.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.M.,Sideris, S.,Tam, C.,Wang, S.,Yeap, S.K.,Yen, I.,Yin, J.,Yu, C.,Zilberleyb, I.,Heffron, T.P. Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57:10176-10191, 2014 Cited by PubMed: 25383627DOI: 10.1021/jm501578n 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.55 Å) |
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