4RJ6

EGFR kinase (T790M/L858R) with inhibitor compound 4

4RJ6 の概要

• エントリーDOI: 10.2210/pdb4rj6/pdb
• 関連するPDBエントリー: 4RJ3 4RJ4 4RJ5 4RJ7 4RJ8
• 分子名称: Epidermal growth factor receptor, SULFATE ION, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-6-amine, ... (4 entities in total)
• 機能のキーワード: protein kinase, phosphotransfer catalyst, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38036.89

構造登録者

Eigenbrot, C.,Yu, C. (登録日: 2014-10-08, 公開日: 2014-11-26, 最終更新日: 2023-09-20)

• 主引用文献: Hanan, E.J.,Eigenbrot, C.,Bryan, M.C.,Burdick, D.J.,Chan, B.K.,Chen, Y.,Dotson, J.,Heald, R.A.,Jackson, P.S.,La, H.,Lainchbury, M.D.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.M.,Sideris, S.,Tam, C.,Wang, S.,Yeap, S.K.,Yen, I.,Yin, J.,Yu, C.,Zilberleyb, I.,Heffron, T.P.; Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation.; J.Med.Chem., 57:10176-10191, 2014; PubMed: 25383627; DOI: 10.1021/jm501578n

実験手法

X-RAY DIFFRACTION (2.7 Å)