4RJ3

CDK2 with EGFR inhibitor compound 8

Summary for 4RJ3

• Entry DOI: 10.2210/pdb4rj3/pdb
• Related: 4RJ4 4RJ5 4RJ6 4RJ7 4RJ8
• Descriptor: Cyclin-dependent kinase 2, ACETATE ION, 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine, ... (4 entities in total)
• Functional Keywords: protein kinase, phosphotransfer catalyst, lysine acetylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
• Total number of polymer chains: 1
• Total formula weight: 34469.06

Authors

Eigenbrot, C.,Yin, J. (deposition date: 2014-10-08, release date: 2014-11-26, Last modification date: 2015-01-14)

• Primary citation: Hanan, E.J.,Eigenbrot, C.,Bryan, M.C.,Burdick, D.J.,Chan, B.K.,Chen, Y.,Dotson, J.,Heald, R.A.,Jackson, P.S.,La, H.,Lainchbury, M.D.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.M.,Sideris, S.,Tam, C.,Wang, S.,Yeap, S.K.,Yen, I.,Yin, J.,Yu, C.,Zilberleyb, I.,Heffron, T.P.; Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation.; J.Med.Chem., 57:10176-10191, 2014; PubMed: 25383627; DOI: 10.1021/jm501578n

Experimental method

X-RAY DIFFRACTION (1.63 Å)