4RIK
Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 69-77
Summary for 4RIK
Entry DOI | 10.2210/pdb4rik/pdb |
Descriptor | Alpha-synuclein (2 entities in total) |
Functional Keywords | amyloid, alpha-synuclein, parkinson's disease, toxic core, nac, lipid binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol : P37840 |
Total number of polymer chains | 1 |
Total formula weight | 815.95 |
Authors | Guenther, E.L.,Sawaya, M.R.,Ivanova, M.,Eisenberg, D.S. (deposition date: 2014-10-06, release date: 2015-08-26, Last modification date: 2024-04-03) |
Primary citation | Rodriguez, J.A.,Ivanova, M.I.,Sawaya, M.R.,Cascio, D.,Reyes, F.E.,Shi, D.,Sangwan, S.,Guenther, E.L.,Johnson, L.M.,Zhang, M.,Jiang, L.,Arbing, M.A.,Nannenga, B.L.,Hattne, J.,Whitelegge, J.,Brewster, A.S.,Messerschmidt, M.,Boutet, S.,Sauter, N.K.,Gonen, T.,Eisenberg, D.S. Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525:486-490, 2015 Cited by PubMed: 26352473DOI: 10.1038/nature15368 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.854 Å) |
Structure validation
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