4RAQ
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents
4RAQ の概要
エントリーDOI | 10.2210/pdb4raq/pdb |
関連するPDBエントリー | 4RAB 4RAC 4RAD 4RAN 4RAO |
分子名称 | Hypoxanthine-guanine phosphoribosyltransferase, [(2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-phosphonoethyl)amino}ethoxy)methyl]phosphonic acid, MAGNESIUM ION, ... (4 entities in total) |
機能のキーワード | hypoxanthine-guanine phosphoribosyltransferase, acyclic nucleoside monophosphonates, malaria, 6-oxopurine phosphoribosyltransferase, 9-[(n-phosphonoethyl-n-phosphonomethoxyethyl)-2-aminoethyl]hypoxanthine, cytoplasmic, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P00492 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 99820.39 |
構造登録者 | Keough, D.T.,Hockova, D.,Janeba, Z.,Wang, T.-H.,Naesens, L.,Edstein, M.D.,Chavchich, M.,Guddat, L.W. (登録日: 2014-09-10, 公開日: 2015-01-07, 最終更新日: 2024-02-28) |
主引用文献 | Keough, D.T.,Hockova, D.,Janeba, Z.,Wang, T.H.,Naesens, L.,Edstein, M.D.,Chavchich, M.,Guddat, L.W. Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents. J.Med.Chem., 58:827-846, 2015 Cited by PubMed: 25494538DOI: 10.1021/jm501416t 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.53 Å) |
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